CASY-MSCCN Jobs

Technical Development Scientist Location: South San Francisco, CA Duration: 12 Months Description: Job Knowledge & Scope: RMG, in the Cell Culture and Bioprocess Operations department, is responsible for providing support to pre-Early-Stage Research to Early Development projects with high-throughput protein production from mammalian transient cultures. We are looking for a motivated candidate with cell culture and sterile technique experience to join our team to enable protein production at Client and help advance our portfolio. Key Responsibilities: Perform transient transfections in CHO and HEK293 cells in scales 1mL to 25L to support pipeline productions adhering to established protocols Maintain seed train cell cultures in bioreactors and shake flasks Operate liquid handlers - Tecan and Hamilton for automated processes Operate wave bag reactors for productions and cell maintenance Maintain and troubleshoot key cell culture instruments such as Vi-Cell, Nova Flex2, Nova Flex, Cedex and bioreactors Participate in troubleshooting production or platform processes Participate in lab management and data management. Contribute to improving existing cell culture platforms and developing new platforms to deliver diverse protein and cellular reagents to enable a large number of research programs. The candidate must be highly self-motivated, organized, detail oriented and responsive to feedback. The candidate is expected to precisely follow written procedures, practice sterile technique, demonstrate accurate documentation skills, and report deviations in a timely manner. They should be able to work independently within guidelines and policies, with minimal guidance. Qualifications: Required PhD (with 0-2yrs relevant experience) in Biotechnology, Chemistry, Biochemistry or related fields Suspension adapted mammalian cell culture (CHO and/or HEK293) Excellent written and verbal communication skills, and have strong collaborative skills. Preferred State-of-the-art transient and stable protein expression experience Relevant bioreactor experience Hands-on experience with automation and liquid handlers like Tecan Freedom Evo and Hamilton Microlab Star Knowledge of cell biology, cell engineering, molecular biology, recombinant protein purification and protein characterization is preferred.

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