Biogen Scientist/Sr. Engineer II, MFG Sciences in Research Triangle Park, North Carolina
About This Role * The Scientist/Sr. Engineer – ASO will contribute as a subject matter expert for anti-sense oligonucleotides (ASO) manufactured at Biogen. They will provide technical expertise on purification methods and strategies while being expected to contribute on synthesis technology and its application in manufacturing. They will lead technical process investigations and demonstrate the capability to lead ASO operations' tech transfer for manufacturing processes. *What You’ll Do * * Develop and qualify laboratory models and perform laboratory experiments towards process optimization or robustness. The work requires collaborative skills and will be coordinated with activities in RTP, NC, and Cambridge, MA. * Design studies and effectively and efficiently communicate results and decisions to the technology transfer team, site management, and other Biogen groups. * Author technical, developmental, and validation reports independently. Provide data and reports to support process robustness/understanding, investigations, and regulatory submissions as needed * Contribute on technology transfers by conducting/coordinating laboratory experiments and guiding implementation of process parameters or controls for manufacturing processes. * Lead multi-functional teams on technical projects towards improved facility capabilities, efficient systems, improved technical competency, or increased process/scale-up understanding. *Who You Are * You are a highly motivated and creative individual with applicable knowledge for the GMP production of ASO drug substances. You are passionate in exploring novel science-based strategies and excited for hands-on work to define the cutting-edge technologies used at Biogen. *Required Skills * * Degree in Chemical Engineering or a related discipline. * MS with 10 years applicable experience. * BS with 12 years applicable experience. * Technical knowledge in biopharmaceutical manufacturing and/or process development. * Excellent communication skills; ease and comfort in interacting with various teams in identifying solutions to support manufacturing activities. *Preferred Skills * PhD with 2-4 years of applied experience * Prior experience with ASO synthesis and purification operations * Experience with data management/systems *Why Biogen? * Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.